In Vitro Inhibitory Activity of Justicia adhatoda Extracts against Influenza Virus Infection and Hemagglutination
نویسندگان
چکیده
The influenza viruses are major etiologic agents of human respiratory infections, and inflict sizable health and economic burden. The present study reports the in vitro antiviral effect of Justicia adhatoda crude extracts against influenza virus by Hemagglutination (HA) reduction in two different layouts of simultaneous and post treatment assay. The aqueous and methanolic extracts were used for antiviral activity in the non-cytotoxic range. Methanolic extract showed 100% reduction in HA in the simultaneous and post treatment assays at the concentration of 10mg/ml. The aqueous extracts at concentrations of 10mg/ml and 5mg/ml reduced the HA to 33% and 16.67%, respectively, in the simultaneous assay. These results suggest that extracts have strong anti-influenza virus activity that can inhibit viral attachment and/or viral replication, and may be used as viral prophylaxis.
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